Calcineurin, Mitochondrial Membrane Potential, and Cardiomyocyte Apoptosis
نویسندگان
چکیده
منابع مشابه
Calcineurin, mitochondrial membrane potential, and cardiomyocyte apoptosis.
Calcineurin, Mitochondrial Membrane Potential, and Cardiomyocyte Apoptosis Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/hh1201.093159 2001;88:1220-1222 Circ Res. http://circres.ahajournals.org/content/8...
متن کاملMitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling.
Mitochondrial morphology is crucial for tissue homeostasis, but its role in cell differentiation is unclear. We found that mitochondrial fusion was required for proper cardiomyocyte development. Ablation of mitochondrial fusion proteins Mitofusin 1 and 2 in the embryonic mouse heart, or gene-trapping of Mitofusin 2 or Optic atrophy 1 in mouse embryonic stem cells (ESCs), arrested mouse heart de...
متن کاملMitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis.
AIMS The cascade of events leading to compromised mitochondrial integrity in response to stress is mediated by various combinatorial interactions of pro- and anti-apoptotic molecules. Nur77, an immediate early gene that encodes a nuclear orphan receptor, translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis in cancer cells in response to various pro-apoptoti...
متن کاملThe effect of aminoguanidine on sperm motility and mitochondrial membrane potential in varicocelized rats
Objective(s): Increased levels of nitric oxide (NO) in the testicular veins of people suffering from varicocele have already been reported. However, the role of NO-synthase (NOS) isozymes and their inhibitors have not been extensively studied. We aimed to evaluate the inhibitory effects of aminoguanidine (AG), on sperm motility, vitality, and mitochondrial membrane potential (MMP) in varicoceli...
متن کاملChanges in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.
AIMS In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated whether activation of apoptosis with ceramides affects mitochondrial dynamics and promotes mitochondrial fission in cardiomyocytes. METHODS AND RESULTS Neonatal rat cardiomyocy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh1201.093159